| SEASON - PITCHING RECORDS | ||||||||||
| WINS | ERA (minimum 27 starts) | |||||||||
| Year | Pitcher | ERA | IP | W | Year | Pitcher | IP | W | ERA | |
| 2004 | Mussina, Mike | 2.80 | 234.7 | 26 | 2003 | Moyer, Jamie | 253.7 | 19 | 2.70 | |
| 2002 | Vazquez, Javier | 3.12 | 245.0 | 21 | 2004 | Mussina, Mike | 234.7 | 26 | 2.80 | |
| 1997 | Reynolds, Shane | 5.34 | 273.0 | 20 | 2007 | Mussina, Mike | 216.7 | 20 | 2.82 | |
| 2007 | Mussina, Mike | 2.82 | 216.7 | 20 | 1991 | Boyd, Oil Can | 187.0 | 10 | 2.98 | |
| 2007 | Escobar, Kelvim | 3.22 | 207.0 | 20 | 2002 | Vazquez, Javier | 245.0 | 21 | 3.12 | |
| INNINGS PITCHED | SAVES | |||||||||
| Year | Pitcher | ERA | W | IP | Year | Pitcher | G | ERA | SV | |
| 1997 | Reynolds, Shane | 5.34 | 20 | 273.0 | 1995 | Jackson, Mike | 58 | 2.61 | 42 | |
| 1997 | Hill, Ken | 5.06 | 13 | 256.3 | 2007 | Rodriguez, Francisco | 69 | 3.37 | 42 | |
| 2003 | Moyer, Jamie | 2.70 | 19 | 253.7 | 2005 | Benitez, Armando | 66 | 3.01 | 42 | |
| 1995 | McDonald, Ben | 5.06 | 18 | 252.7 | 2002 | Karsay, Steve | 74 | 3.00 | 39 | |
| 2004 | Vazquez, Javier | 3.78 | 13 | 252.3 | 1999 | Aguilera, Rick | 64 | 4.21 | 35 | |
| 2001 | Koch, Billy | 61 | 3.44 | 35 | ||||||
| GAMES PITCHED | WINNING PERCENTAGE (minimum 27 starts) | |||||||||
| Year | Pitcher | ERA | IP | G | Year | Pitcher | W | L | Win % | |
| 1995 | Slocumb, Heath | 4.05 | 124.3 | 88 | 2004 | Mussina, Mike | 26 | 4 | 0.867 | |
| 2003 | Koch, Billy | 3.08 | 96.3 | 81 | 2007 | Escobar, Kelvim | 20 | 4 | 0.833 | |
| 1999 | Telemaco, Amaury | 5.43 | 119.3 | 80 | 2002 | Vazquez, Javier | 21 | 6 | 0.778 | |
| 1996 | Williams, Mike | 4.05 | 131.0 | 78 | 2007 | Mussina, Mike | 20 | 6 | 0.769 | |
| 1997 | Worrell, Tim | 3.96 | 147.7 | 76 | 2001 | Vazquez, Javier | 17 | 6 | 0.739 | |
| STRIKE OUTS | WALKS | |||||||||
| Year | Pitcher | IP | BB | K | Year | Pitcher | ERA | K | BB | |
| 2001 | Park, Chan Ho | 241.7 | 156 | 244 | 2001 | Park, Chan Ho | 4.66 | 244 | 156 | |
| 2004 | Vazquez, Javier | 252.3 | 83 | 237 | 2004 | Zito, Barry | 4.36 | 151 | 117 | |
| 2002 | Vazquez, Javier | 245.0 | 54 | 234 | 1993 | Hill, Ken | 3.41 | 146 | 116 | |
| 1997 | Reynolds, Shane | 273.0 | 73 | 218 | 2000 | Cone, David | 4.67 | 193 | 114 | |
| 2004 | Mussina, Mike | 234.7 | 49 | 207 | 2006 | Zito, Barry | 4.06 | 186 | 113 | |
| 2003 | Mussina, Mike | 233.0 | 74 | 207 | ||||||
| LOSSES | HOMERUNS ALLOWED | |||||||||
| Year | Pitcher | ERA | W | L | Year | Pitcher | IP | ERA | HR | |
| 1998 | Hampton, Mike | 6.07 | 7 | 18 | 2005 | Zito, Barry | 230.3 | 6.29 | 52 | |
| 2002 | Zito, Barry | 4.82 | 14 | 17 | 1997 | Reynolds, Shane | 273.0 | 5.34 | 46 | |
| 1993 | Hill, Ken | 3.41 | 11 | 17 | 2003 | Zito, Barry | 248.3 | 3.70 | 45 | |
| 2006 | Zito, Barry | 4.06 | 11 | 17 | 1997 | Hill, Ken | 256.3 | 5.06 | 39 | |
| 2003 | Vazquez, Javier | 5.22 | 11 | 15 | 2005 | Vazquez, Javier | 219.7 | 3.93 | 39 | |
| 2005 | Zito, Barry | 6.29 | 10 | 15 | 2003 | Mussina, Mike | 233.0 | 5.06 | 39 | |
| 1995 | Tapani, Kevin | 5.56 | 12 | 15 | ||||||
| SHUTOUTS | ||||||||||
| Year | Pitcher | W | L | SH | ||||||
| 1992 | Hill, Ken | 16 | 8 | 2 | ||||||
| 2006 | Vazquez, Javier | 14 | 11 | 2 | ||||||
| 2003 | Zito, Barry | 19 | 11 | 2 | ||||||
| 2005 | Vazquez, Javier | 14 | 11 | 2 | ||||||
| 2004 | Mussina, Mike | 26 | 4 | 2 | ||||||
| 1995 | Mahomes, Pat | 5 | 2 | 2 | ||||||
| 2002 | Buehrle, Mark | 12 | 9 | 2 | ||||||