| Pitcher | ERA | W | L | Win % | G | GS | CG | SH | SV | IP | H | R | ER | HR | BB | K |
| Vazquez, Javier Total | 4.27 | 111 | 68 | 0.620 | 254 | 254 | 30 | 7 | 0 | 1714.0 | 1768 | 864 | 813 | 220 | 490 | 1406 |
| Hill, Ken Total | 4.72 | 79 | 82 | 0.491 | 210 | 210 | 13 | 4 | 0 | 1419.3 | 1545 | 838 | 745 | 151 | 600 | 817 |
| Zito, Barry Total | 4.38 | 80 | 77 | 0.510 | 192 | 192 | 22 | 4 | 0 | 1294.7 | 1224 | 696 | 630 | 202 | 572 | 1010 |
| Tapani, Kevin Total | 4.90 | 61 | 58 | 0.513 | 169 | 165 | 17 | 2 | 0 | 1123.3 | 1288 | 679 | 612 | 126 | 309 | 714 |
| McDonald, Ben Total | 4.45 | 64 | 48 | 0.571 | 148 | 147 | 13 | 1 | 0 | 983.0 | 1024 | 564 | 486 | 124 | 366 | 646 |
| Mussina, Mike Total | 3.82 | 80 | 34 | 0.702 | 135 | 135 | 18 | 4 | 0 | 928.0 | 896 | 428 | 394 | 125 | 225 | 785 |
| Clark, Mark Total | 4.68 | 34 | 39 | 0.466 | 101 | 101 | 20 | 1 | 0 | 707.0 | 799 | 421 | 368 | 104 | 192 | 339 |
| Reynolds, Shane Total | 4.93 | 41 | 30 | 0.577 | 121 | 84 | 11 | 1 | 0 | 640.7 | 767 | 383 | 351 | 95 | 155 | 523 |
| Leibrandt, Charlie Total | 4.18 | 35 | 35 | 0.500 | 96 | 96 | 3 | 1 | 0 | 622.3 | 656 | 314 | 289 | 72 | 177 | 289 |
| Dotel, Octavio Total | 4.24 | 43 | 23 | 0.652 | 351 | 14 | 0 | 0 | 45 | 581.7 | 476 | 291 | 274 | 100 | 280 | 670 |
| Lieber, Jon Total | 4.22 | 32 | 26 | 0.552 | 85 | 85 | 6 | 1 | 0 | 571.0 | 620 | 285 | 268 | 88 | 102 | 331 |
| Jackson, Mike Total | 3.33 | 27 | 42 | 0.391 | 440 | 0 | 0 | 0 | 133 | 562.0 | 519 | 237 | 208 | 56 | 209 | 484 |
| Greene, Tommy Total | 3.51 | 32 | 18 | 0.640 | 81 | 67 | 2 | 2 | 1 | 487.0 | 413 | 200 | 190 | 48 | 179 | 323 |
| Radke, Brad Total | 4.38 | 29 | 21 | 0.580 | 65 | 65 | 6 | 1 | 0 | 452.0 | 502 | 242 | 220 | 61 | 108 | 270 |
| Fernandez, Alex Total | 4.78 | 32 | 20 | 0.615 | 64 | 64 | 8 | 2 | 0 | 439.0 | 469 | 259 | 233 | 60 | 188 | 301 |
| Rueter, Kirk Total | 5.06 | 23 | 21 | 0.523 | 63 | 63 | 9 | 2 | 0 | 434.0 | 515 | 276 | 244 | 68 | 141 | 185 |
| Morris, Matt Total | 4.46 | 27 | 21 | 0.563 | 61 | 61 | 5 | 1 | 0 | 407.3 | 458 | 218 | 202 | 67 | 108 | 221 |
| Cordova, Fransisco Total | 3.88 | 26 | 19 | 0.578 | 57 | 57 | 2 | 0 | 0 | 398.7 | 402 | 197 | 172 | 48 | 126 | 228 |
| Boyd, Oil Can Total | 3.56 | 17 | 14 | 0.548 | 49 | 49 | 2 | 1 | 0 | 311.0 | 287 | 131 | 123 | 22 | 99 | 174 |
| Koch, Billy Total | 3.33 | 13 | 16 | 0.448 | 269 | 0 | 0 | 0 | 66 | 297.7 | 262 | 119 | 110 | 29 | 130 | 267 |
| Hernandez, Livan Total | 4.66 | 17 | 10 | 0.630 | 40 | 39 | 5 | 1 | 0 | 272.3 | 302 | 149 | 141 | 36 | 121 | 187 |
| Heilman, Aaron Total | 3.86 | 14 | 17 | 0.452 | 149 | 11 | 1 | 0 | 2 | 270.7 | 256 | 125 | 116 | 34 | 138 | 232 |
| Escobar, Kelvim Total | 3.14 | 26 | 9 | 0.743 | 78 | 32 | 2 | 0 | 3 | 269.7 | 211 | 103 | 94 | 26 | 84 | 228 |
| Plesac, Dan Total | 4.23 | 4 | 5 | 0.444 | 212 | 0 | 0 | 0 | 9 | 263.7 | 244 | 131 | 124 | 47 | 106 | 224 |
| Ojeda, Bob Total | 5.07 | 8 | 14 | 0.364 | 59 | 26 | 2 | 0 | 2 | 259.3 | 287 | 158 | 146 | 32 | 105 | 157 |
| Moyer, Jamie Total | 2.70 | 19 | 8 | 0.704 | 35 | 35 | 2 | 1 | 0 | 253.7 | 226 | 83 | 76 | 28 | 45 | 149 |
| Slocumb, Heath Total | 4.55 | 12 | 19 | 0.387 | 198 | 0 | 0 | 0 | 27 | 253.0 | 241 | 148 | 128 | 30 | 139 | 213 |
| Patterson, John Total | 4.51 | 14 | 8 | 0.636 | 55 | 33 | 0 | 0 | 3 | 251.7 | 248 | 135 | 126 | 35 | 87 | 227 |
| Benitez, Armando Total | 4.08 | 19 | 7 | 0.731 | 235 | 0 | 0 | 0 | 50 | 249.3 | 205 | 125 | 113 | 46 | 97 | 231 |
| Contreras, Jose Total | 3.59 | 16 | 12 | 0.571 | 83 | 22 | 5 | 1 | 0 | 243.0 | 216 | 108 | 97 | 33 | 93 | 185 |
| Park, Chan Ho Total | 4.66 | 14 | 13 | 0.519 | 35 | 35 | 0 | 0 | 0 | 241.7 | 213 | 143 | 125 | 32 | 156 | 244 |
| Cordero, Chad Total | 3.94 | 19 | 9 | 0.679 | 171 | 0 | 0 | 0 | 31 | 240.0 | 208 | 109 | 105 | 44 | 101 | 201 |
| Gordon, Tom Total | 2.22 | 18 | 10 | 0.643 | 195 | 0 | 0 | 0 | 9 | 238.7 | 155 | 65 | 59 | 18 | 73 | 245 |
| Hampton, Mike Total | 6.07 | 7 | 18 | 0.280 | 32 | 32 | 7 | 0 | 0 | 229.7 | 290 | 172 | 155 | 34 | 96 | 129 |
| Willis, Carl Total | 3.53 | 17 | 16 | 0.515 | 174 | 0 | 0 | 0 | 29 | 226.7 | 229 | 98 | 89 | 17 | 66 | 148 |
| Perez, Carlos Total | 3.51 | 13 | 7 | 0.650 | 29 | 29 | 7 | 0 | 0 | 225.7 | 238 | 107 | 88 | 32 | 53 | 113 |
| Pavlik, Roger Total | 5.24 | 10 | 14 | 0.417 | 31 | 31 | 7 | 0 | 0 | 213.0 | 238 | 150 | 124 | 23 | 105 | 151 |
| Cone, David Total | 4.67 | 12 | 7 | 0.632 | 31 | 31 | 3 | 1 | 0 | 208.3 | 200 | 113 | 108 | 25 | 114 | 193 |
| Fernandez, Sid Total | 2.90 | 18 | 8 | 0.692 | 32 | 32 | 2 | 0 | 0 | 208.0 | 153 | 70 | 67 | 21 | 81 | 215 |
| Aguilera, Rick Total | 3.62 | 9 | 23 | 0.281 | 182 | 0 | 0 | 0 | 65 | 201.3 | 217 | 94 | 81 | 27 | 54 | 160 |
| Wall, Donnie Total | 4.40 | 16 | 22 | 0.421 | 155 | 0 | 0 | 0 | 2 | 198.3 | 197 | 113 | 97 | 34 | 76 | 140 |
| Trachsel, Steve Total | 4.77 | 15 | 7 | 0.682 | 29 | 29 | 3 | 0 | 0 | 188.7 | 195 | 108 | 100 | 27 | 45 | 133 |
| Ashby, Andy Total | 4.93 | 9 | 12 | 0.429 | 30 | 30 | 0 | 0 | 0 | 188.0 | 229 | 113 | 103 | 30 | 61 | 82 |
| Perez, Mike Total | 3.06 | 11 | 19 | 0.367 | 125 | 0 | 0 | 0 | 22 | 179.7 | 174 | 68 | 61 | 15 | 65 | 101 |
| Buehrle, Mark Total | 4.47 | 12 | 9 | 0.571 | 25 | 25 | 2 | 2 | 0 | 175.3 | 170 | 91 | 87 | 35 | 57 | 94 |
| Moehler, Brian Total | 5.34 | 12 | 8 | 0.600 | 27 | 27 | 0 | 0 | 0 | 173.7 | 245 | 106 | 103 | 19 | 50 | 96 |
| Mason, Roger Total | 4.35 | 13 | 5 | 0.722 | 114 | 0 | 0 | 0 | 3 | 165.7 | 166 | 81 | 80 | 24 | 60 | 118 |
| Deshaies, Jim Total | 3.95 | 12 | 11 | 0.522 | 25 | 25 | 2 | 0 | 0 | 152.7 | 135 | 73 | 67 | 19 | 71 | 96 |
| Martinez, Ramon Total | 3.49 | 15 | 4 | 0.789 | 22 | 22 | 1 | 0 | 0 | 149.7 | 119 | 63 | 58 | 20 | 59 | 118 |
| Leary, Tim Total | 5.24 | 7 | 12 | 0.368 | 22 | 22 | 3 | 1 | 0 | 149.3 | 167 | 93 | 87 | 18 | 63 | 96 |
| Worrell, Tim Total | 3.96 | 10 | 7 | 0.588 | 76 | 3 | 0 | 0 | 6 | 147.7 | 142 | 75 | 65 | 24 | 60 | 100 |
| Telemaco, Amaury Total | 5.92 | 6 | 9 | 0.400 | 94 | 0 | 0 | 0 | 1 | 143.0 | 168 | 102 | 94 | 20 | 53 | 71 |
| Williams, Mike Total | 4.05 | 7 | 6 | 0.538 | 78 | 0 | 0 | 0 | 4 | 131.0 | 109 | 65 | 59 | 26 | 37 | 71 |
| Alvarez, Wilson Total | 5.18 | 4 | 9 | 0.308 | 20 | 20 | 0 | 0 | 0 | 130.3 | 136 | 84 | 75 | 21 | 74 | 92 |
| Maine, John Total | 3.91 | 11 | 8 | 0.579 | 21 | 20 | 1 | 1 | 0 | 129.0 | 105 | 59 | 56 | 19 | 48 | 95 |
| Fossas, Tony Total | 5.05 | 4 | 4 | 0.500 | 130 | 0 | 0 | 0 | 3 | 123.0 | 118 | 72 | 69 | 23 | 54 | 108 |
| Valdes, Marc Total | 3.68 | 8 | 14 | 0.364 | 64 | 0 | 0 | 0 | 2 | 119.7 | 113 | 52 | 49 | 12 | 45 | 59 |
| Rose, Brian Total | 3.88 | 3 | 3 | 0.500 | 56 | 2 | 0 | 0 | 4 | 118.3 | 121 | 56 | 51 | 19 | 33 | 61 |
| Kennedy, Joe Total | 4.03 | 7 | 5 | 0.583 | 19 | 19 | 1 | 0 | 0 | 116.0 | 121 | 60 | 52 | 12 | 41 | 72 |
| Francis, Jeff Total | 5.79 | 7 | 8 | 0.467 | 17 | 17 | 1 | 1 | 0 | 112.0 | 134 | 76 | 72 | 21 | 35 | 73 |
| Merker, Kent Total | 5.02 | 9 | 11 | 0.450 | 99 | 1 | 0 | 0 | 22 | 107.7 | 105 | 61 | 60 | 12 | 53 | 73 |
| Mantei, Matt Total | 5.40 | 7 | 6 | 0.538 | 105 | 0 | 0 | 0 | 23 | 105.0 | 107 | 68 | 63 | 19 | 51 | 108 |
| Hartley, Mike Total | 4.40 | 1 | 7 | 0.125 | 63 | 0 | 0 | 0 | 8 | 104.3 | 87 | 53 | 51 | 17 | 44 | 75 |
| Glover, Gary Total | 5.52 | 7 | 5 | 0.583 | 69 | 0 | 0 | 0 | 1 | 102.7 | 126 | 68 | 63 | 19 | 38 | 58 |
| Welch, Bob Total | 2.52 | 7 | 5 | 0.583 | 15 | 15 | 1 | 1 | 0 | 100.0 | 88 | 31 | 28 | 8 | 39 | 36 |
| Ainsworth, Kurt Total | 4.56 | 6 | 5 | 0.545 | 32 | 12 | 0 | 0 | 0 | 98.7 | 102 | 52 | 50 | 9 | 45 | 67 |
| Reardon, Jeff Total | 3.12 | 5 | 7 | 0.417 | 87 | 0 | 0 | 0 | 13 | 98.0 | 85 | 40 | 34 | 6 | 26 | 80 |
| Sowers, Jeremy Total | 2.68 | 7 | 2 | 0.778 | 14 | 14 | 1 | 1 | 0 | 97.3 | 85 | 30 | 29 | 13 | 19 | 40 |
| Karsay, Steve Total | 3.00 | 4 | 5 | 0.444 | 74 | 0 | 0 | 0 | 39 | 90.0 | 81 | 34 | 30 | 8 | 21 | 90 |
| Gobble, Jimmy Total | 4.69 | 5 | 2 | 0.714 | 13 | 13 | 1 | 0 | 0 | 88.3 | 96 | 49 | 46 | 16 | 24 | 40 |
| Olsen, Scott Total | 7.17 | 4 | 3 | 0.571 | 19 | 12 | 2 | 0 | 0 | 86.7 | 108 | 72 | 69 | 14 | 50 | 77 |
| Henry, Doug Total | 5.55 | 5 | 5 | 0.500 | 66 | 0 | 0 | 0 | 1 | 84.3 | 71 | 56 | 52 | 22 | 60 | 61 |
| Mahomes, Pat Total | 4.45 | 5 | 2 | 0.714 | 19 | 11 | 2 | 2 | 1 | 83.0 | 96 | 42 | 41 | 14 | 36 | 47 |
| Stauffer, Tim Total | 7.84 | 4 | 8 | 0.333 | 15 | 15 | 0 | 0 | 0 | 80.3 | 126 | 73 | 70 | 15 | 37 | 42 |
| Rodriguez, Francisco Total | 3.37 | 2 | 4 | 0.333 | 69 | 0 | 0 | 0 | 42 | 74.7 | 51 | 28 | 28 | 13 | 28 | 105 |
| Lyon, Brandon Total | 4.96 | 2 | 4 | 0.333 | 11 | 11 | 0 | 0 | 0 | 69.0 | 64 | 43 | 38 | 8 | 21 | 38 |
| Hutton, Mark Total | 6.23 | 6 | 2 | 0.750 | 28 | 6 | 0 | 0 | 0 | 60.7 | 64 | 47 | 42 | 10 | 31 | 21 |
| Wunsch, Kelly Total | 5.29 | 2 | 1 | 0.667 | 55 | 0 | 0 | 0 | 1 | 47.7 | 40 | 28 | 28 | 6 | 45 | 32 |
| Myers, Mike Total | 4.43 | 0 | 1 | 0.000 | 51 | 0 | 0 | 0 | 1 | 44.7 | 30 | 25 | 22 | 5 | 25 | 38 |
| Anderson, Jimmy Total | 2.30 | 3 | 2 | 0.600 | 8 | 5 | 2 | 0 | 1 | 43.0 | 25 | 12 | 11 | 1 | 21 | 14 |
| Pugh, Tim Total | 6.48 | 1 | 3 | 0.250 | 7 | 7 | 0 | 0 | 0 | 41.7 | 61 | 32 | 30 | 2 | 20 | 19 |
| Ledezma, Wil Total | 4.43 | 0 | 0 | #DIV/0! | 27 | 0 | 0 | 0 | 3 | 40.7 | 43 | 23 | 20 | 1 | 18 | 24 |
| Miceli, Dan Total | 2.95 | 4 | 2 | 0.667 | 28 | 0 | 0 | 0 | 0 | 39.7 | 37 | 13 | 13 | 4 | 16 | 28 |
| Wright, Jaret Total | 4.26 | 4 | 2 | 0.667 | 6 | 6 | 0 | 0 | 0 | 38.0 | 31 | 18 | 18 | 4 | 26 | 23 |
| Stanton, Mike Total | 1.93 | 0 | 1 | 0.000 | 22 | 0 | 0 | 0 | 4 | 37.3 | 30 | 8 | 8 | 1 | 14 | 20 |
| Ayrault, Bob Total | 5.89 | 3 | 0 | 1.000 | 35 | 0 | 0 | 0 | 0 | 36.7 | 42 | 25 | 24 | 2 | 18 | 16 |
| Tankersley, Dennis Total | 6.06 | 2 | 0 | 1.000 | 27 | 0 | 0 | 0 | 0 | 35.7 | 43 | 24 | 24 | 3 | 14 | 30 |
| Andujar, Luis Total | 7.27 | 1 | 1 | 0.500 | 5 | 5 | 0 | 0 | 0 | 26.0 | 40 | 21 | 21 | 4 | 15 | 7 |
| Gonzalez, Mike Total | 1.08 | 1 | 0 | 1.000 | 19 | 0 | 0 | 0 | 4 | 25.0 | 19 | 3 | 3 | 0 | 6 | 30 |
| Powell, Dennis Total | 4.63 | 0 | 0 | #DIV/0! | 18 | 0 | 0 | 0 | 1 | 23.3 | 24 | 13 | 12 | 6 | 6 | 20 |
| Gubizca, Mark Total | 4.60 | 2 | 1 | 0.667 | 3 | 3 | 0 | 0 | 0 | 15.7 | 15 | 8 | 8 | 1 | 9 | 14 |
| Davis, Mark Total | 0.66 | 0 | 0 | #DIV/0! | 6 | 0 | 0 | 0 | 1 | 13.7 | 9 | 1 | 1 | 0 | 6 | 9 |
| Chen, Bruce Total | 2.08 | 1 | 0 | 1.000 | 2 | 2 | 0 | 0 | 0 | 13.0 | 11 | 3 | 3 | 2 | 4 | 7 |
| Volquez, Endison Total | 7.04 | 0 | 0 | #DIV/0! | 4 | 0 | 0 | 0 | 0 | 7.7 | 9 | 6 | 6 | 2 | 9 | 4 |
| Capellan, Jose Total | 5.14 | 0 | 0 | #DIV/0! | 5 | 0 | 0 | 0 | 0 | 7.0 | 7 | 4 | 4 | 1 | 3 | 6 |
| Grand Total | 4.32 | 1471 | 1225 | 0.546 | 7342 | 2696 | 253 | 48 | 688 | 24250.9 | 24589 | 12752 | 11629 | 3192 | 8655 | 17090 |